Moderate-HighGBS: 88 (High Risk)nutrition

Alzheimer's Prevention Protocol (Bredesen ReCODE)

Developer: Dale Bredesen

Prevention: lifelong; MCI/early AD: 6-12 months to see improvement

Protocol Overview

Comprehensive precision-medicine protocol addressing 36+ contributing factors to Alzheimer's disease. Based on Dr. Bredesen's research showing reversal of early-stage AD with multi-modal approach.

Conditions Treated

Alzheimer's disease

mild cognitive impairment

prevention

Protocol Steps

Testing (comprehensive "cognoscopy"): Blood work (insulin, glucose, A1C, lipids, homocysteine, CRP, vitamins B12/D, thyroid, hormones), genetics (ApoE4 status), MRI with volumetrics, cognitive testing (MoCA, neuropsych), advanced labs (copper/zinc ratio, mercury, omega-3 index, organic acids)

Identify subtype: Type 1 inflammatory (CRP elevated, infections), Type 2 atrophic (low trophic support - hormones, nutrients, insulin resistance), Type 3 toxic (mycotoxins, metals, organic toxins), Type 4 vascular, Type 5 traumatic

Ketogenic diet or KetoFlex 12/3: Mild ketosis (beta-hydroxybutyrate 0.5-4 mmol), low glycemic, plant-rich, 12-14 hour fast overnight, last meal 3 hours before bed, avoid simple carbs/sugar

Insulin optimization: Fasting insulin <7, A1C <5.5, avoid insulin resistance (Alzheimer's is "Type 3 diabetes")

Exercise: Aerobic 30-60 min 4-5x/week + strength training (increases BDNF, glucose metabolism, brain perfusion)

Sleep: 7-8 hours, treat sleep apnea (huge AD risk factor), melatonin 0.3-20mg (also antioxidant)

Stress reduction: Chronic cortisol damages hippocampus - meditation, yoga, therapy

Optimize hormones: Thyroid (free T3 upper third), estradiol/testosterone (bioidentical HRT if deficient - protective), progesterone, cortisol, pregnenolone

Vitamin D: Optimize 60-80 ng/ml (40-60 at minimum)

Omega-3: 2-4g EPA/DHA (omega-3 index >8% - structural and anti-inflammatory)

Homocysteine: <7 (methylated B-complex - methylfolate 1mg, methyl-B12 1-5mg, B6 50mg, TMG 500mg)

Antioxidants: Vitamin E (mixed tocopherols 400-800 IU), vitamin C 1-2g, resveratrol 100mg, curcumin 1g, polyphenols (blueberries, green tea)

Mitochondrial support: CoQ10 200-600mg ubiquinol, PQQ 20mg, acetyl-L-carnitine 500mg, alpha-lipoic acid 300-600mg

Citicoline: 500-1000mg (choline for acetylcholine, neuroprotection)

Lion's mane mushroom: 500-1000mg 2x/day (NGF stimulation, neurogenesis)

Bacopa monnieri: 300mg daily (memory enhancement)

Magnesium threonate: 2g daily (only magnesium crossing BBB, synaptic plasticity)

Optimize zinc:copper ratio: Zinc 20-40mg, copper 1-2mg (imbalance implicated in AD)

Detoxification: If Type 3 (toxic), address mold, mercury, organic toxins (see detox protocols)

Treat infections: If Type 1, address Herpes, Lyme, Candida, gut dysbiosis

Brain training: Cognitive stimulation, learning new skills, social engagement

Oral health: Treat periodontal disease (bacteria and inflammation linked to AD), proper dentition (chewing stimulates brain)

Music therapy: Learning instrument, singing (neuroplasticity)

Photobiomodulation: Red/NIR light 810nm transcranial (emerging evidence for cognitive benefits)

Key Resources

The End of Alzheimer's by Dale Bredesen, "The End of Alzheimer's Program" by Bredesen, Apollo Health program, ReCODE Report

Contraindications & Risks

Complex protocol requiring functional medicine practitioner, expensive testing/supplements, hormone replacement needs monitoring

Important Notes

Paradigm shift: Alzheimer's is not one disease but end result of 36+ factors (infections, inflammation, toxins, vascular, metabolic, trophic factor loss). Bredesen's precision medicine approach identifies individual contributors and addresses each. Case series of 100+ patients showing reversal of MCI and early AD (first time in history). Later-stage AD harder to reverse but progression can slow. Key insights: Amyloid is protective response to insults (infections, toxins, inflammation), not primary cause. Insulin resistance central (brain glucose hypometabolism, "Type 3 diabetes"). ApoE4 carriers (25% of population) at higher risk, need more aggressive prevention. Ketones provide alternative brain fuel (ketogenic diet or MCT oil). Sleep apnea massively increases risk (hypoxia, fragmented sleep prevents amyloid clearance). Oral microbiome connection (P. gingivalis found in AD brains). Homocysteine >10 doubles risk. Comprehensive approach is complex but addresses root causes. Prevention is key - protocol most effective before significant damage. Many of same factors prevent vascular dementia. ApoHealth and trained Bredesen practitioners can guide protocol. This is future of Alzheimer's treatment - precision medicine, not one drug.

Also Effective For

Breast Cancer (Integrative Support)

Key Supplements & Herbs in This Protocol

Supplements

Copper L-Carnitine Resveratrol Pregnenolone Butyrate

Herbs

Lion's Mane

Hericium erinaceus

Critical Safety Warning

This protocol is documented for educational purposes only. The Gabriel Bullshit Score (GBS) of 88 reflects significant institutional response and controversy. Some alternative health protocols have resulted in serious harm or death.

Always consult with qualified healthcare professionals before beginning any treatment. Do not delay or forego proven medical care.

Quick Overview

Evidence LevelModerate-High

GBS Score88 / 100

Categorynutrition

DeveloperDale Bredesen

DurationPrevention: lifelong; MCI/early AD: 6-12 months to see improvement

About GBS Score

The Gabriel Bullshit Score reflects the magnitude of institutional response, controversy, and documented concerns. Higher scores indicate greater institutional pushback, not necessarily inefficacy. This is a research tool, not medical advice.