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Comprehensive protocol to restore hypothalamic-pituitary-adrenal (HPA) axis function after chronic stress. Addresses "adrenal fatigue" (controversial term) through evidence-based HPA support.
Testing: 4-point salivary cortisol (morning, noon, evening, night) to assess daily rhythm, DHEA-S, pregnenolone, consider DUTCH test for comprehensive adrenal/sex hormones
Sleep optimization: Absolute priority - 8-9 hours, consistent schedule, dark room, no screens 2 hours before bed, magnesium glycinate 400-600mg before bed, glycine 3g, melatonin 1-3mg if needed
Blood sugar stability: Eat within 30 minutes of waking, protein at every meal (20-30g), avoid refined carbs/sugar, don't skip meals, small snack before bed if waking at night
Adaptogenic herbs (based on cortisol pattern): High cortisol: Phosphatidylserine 300-600mg at night, holy basil 600mg 2x/day, magnolia bark 250mg
Low cortisol: Rhodiola rosea 200-400mg AM, Panax ginseng 400mg AM, cordyceps 1-3g AM, licorice root 300-900mg AM (raises cortisol - avoid if hypertensive)
Balanced support: Ashwagandha KSM-66 600mg 2x/day (modulates - lowers if high, supports if low)
Vitamin C: 2-3g daily in divided doses (adrenals have highest concentration of vitamin C, needed for cortisol production)
B-vitamins: Methylated B-complex (B5 especially important for adrenals - 500mg)
Magnesium: 400-800mg daily (most people deficient, needed for HPA axis)
Salt: If low cortisol/low blood pressure, increase unrefined sea salt (adrenal insufficiency causes salt wasting)
Stress management: Non-negotiable - meditation, deep breathing, therapy, reduce stressors, say no more often, boundaries
Exercise adjustment: If in burnout phase (flat cortisol), only gentle exercise (walking, yoga) - no HIIT or overtraining. As recovery progresses, gradually add intensity
Caffeine: Reduce or eliminate temporarily (whips exhausted adrenals), transition to green tea or decaf
Pregnenolone/DHEA: If very low, supplement pregnenolone 25-50mg AM, DHEA 10-25mg AM (after testing - don't supplement blind)
Avoid: Chronic stress, overtraining, under-eating, stimulants, alcohol
Adrenal fatigue is controversial term (mainstream endocrinology rejects it, but HPA axis dysfunction is real). Adrenal glands don't "fatigue" but HPA axis becomes dysregulated from chronic stress. Classic pattern: Initially high cortisol (stressed, wired), eventually low/flat cortisol (burnout, exhaustion). Salivary cortisol shows daily rhythm (should be high AM, decline during day, low at night). Many have reversed pattern. Sleep is #1 intervention - cortisol rhythm set by sleep/wake. Blood sugar swings stress HPA axis. Adaptogens are intelligent - rhodiola/licorice for low cortisol, phosphatidylserine/holy basil for high cortisol, ashwagandha modulates both directions. Exercise is double-edged: moderate exercise healthy, overtraining worsens HPA dysfunction. Recovery takes time (months to years). Biggest challenge: reducing life stress. Pregnenolone is "mother hormone" - gets shunted to cortisol under stress (pregnenolone steal), depleting sex hormones.
This protocol is documented for educational purposes only. The Gabriel Bullshit Score (GBS) of 79 reflects significant institutional response and controversy. Some alternative health protocols have resulted in serious harm or death.
Always consult with qualified healthcare professionals before beginning any treatment. Do not delay or forego proven medical care.
The Gabriel Bullshit Score reflects the magnitude of institutional response, controversy, and documented concerns. Higher scores indicate greater institutional pushback, not necessarily inefficacy. This is a research tool, not medical advice.
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