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Activates AMPK; improves insulin sensitivity, modulates gut microbiome, antimicrobial
500mg 2-3x/day with meals (1000-1500mg/day total)
Berberine HCl
Works synergistically with:
Not typically a food (from herbs like goldenseal, barberry)
May potentiate diabetes and blood pressure meds; Inhibits CYP3A4; May affect gut flora
Pregnancy; Breastfeeding
"Nature's Metformin"; clinically effective for blood sugar; take with meals; may cause GI upset initially
Statins increase diabetes risk by 44%
Artificial sweeteners disrupt gut microbiome and insulin signaling
Artificial sweeteners linked to weight gain despite zero calories
Type 2 diabetes can be reversed with diet despite "progressive disease" label
Berberine lowers blood sugar as effectively as metformin
BUT: can cause GI upset—start low
Berberine kills pathogenic gut bacteria
BUT: may reduce beneficial bacteria too—pair with probiotics
Berberine activates AMPK for metabolic health
BUT: inhibits CYP450 enzymes—check drug interactions
Berberine requires divided doses (500mg 2-3x daily)
BUT: take with meals to reduce nausea
This information is for educational purposes. Always consult with a qualified healthcare provider before starting any new supplement protocol.
Anti-inflammatory via COX/LOX inhibition and NF-κB modulation; antioxidant, neuroprotective
Adaptogen; reduces cortisol, modulates GABA, supports thyroid, neuroprotective via withanolides
Hepatoprotective via silymarin (antioxidant, promotes glutathione, stabilizes hepatocyte membranes)