ModerateGBS: 80 (High Risk)nutrition

Estrogen Dominance Protocol

Developer: John Lee, Sara Gottfried, functional medicine

3-6 months to rebalance hormones

Protocol Overview

Protocol to reduce estrogen dominance (high estrogen relative to progesterone) through improved estrogen metabolism, detoxification, and progesterone support. Common underlying issue in many female hormone problems.

Conditions Treated

Estrogen dominance

PMS

fibrocystic breasts

heavy periods

mood swings

Protocol Steps

Testing: Day 3 estradiol, Day 21 progesterone, estrogen metabolites (DUTCH test - 2-OH, 4-OH, 16-OH pathways), liver function, gut health

Improve estrogen metabolism: DIM 200-400mg daily OR I3C 400-800mg (shifts estrogen to beneficial 2-hydroxy pathway), calcium-d-glucarate 500mg 2x/day (prevents estrogen reabsorption in gut), sulforaphane from broccoli sprouts, chrysin 500mg

Liver support (estrogen detox): Milk thistle 300mg 2x/day, NAC 600mg 2x/day, methylation support (methylated B-complex - B2, B6, B12, folate, TMG), castor oil packs over liver 3x/week

Gut health (estrogen elimination): Daily bowel movement essential (estrogen reabsorbed if constipated), probiotics with Lactobacillus strains, fiber 35-40g daily, address dysbiosis

Progesterone support: Vitex 400-800mg daily (increases progesterone naturally), vitamin B6 50-100mg P5P, magnesium 400mg, vitamin C 1000mg OR bioidentical progesterone cream 20-40mg days 14-28 of cycle (or day 12-26), topical rotation sites

Reduce xenoestrogens: Eliminate plastics (BPA, phthalates), non-toxic personal care products, organic food (pesticides are endocrine disruptors), filter water (chlorine, fluoride), avoid parabens, triclosan

Diet: Cruciferous vegetables daily (broccoli, cauliflower, Brussels sprouts, cabbage - contain DIM/I3C), flaxseed 2 tbsp ground daily (lignans block estrogen receptors), reduce alcohol (impairs estrogen metabolism), increase fiber, balance blood sugar

Weight loss if needed: Fat tissue produces estrogen (aromatase enzyme) - even 5-10% weight loss reduces estrogen burden

Reduce stress: Chronic stress lowers progesterone (pregnenolone steal to make cortisol)

Avoid conventional HRT/birth control: Synthetic progestins worsen estrogen dominance (use bioidentical if needed)

Key Resources

What Your Doctor May Not Tell You About Premenopause/Menopause by John Lee, "The Hormone Cure" by Sara Gottfried, DUTCH test

Contraindications & Risks

Hormone-sensitive cancers (individualize approach), pregnancy/nursing, medications affecting hormones

Important Notes

Estrogen dominance is ratio problem - can have normal or even low estrogen but still be estrogen dominant relative to progesterone. Causes: Stress (lowers progesterone), poor estrogen metabolism (liver burden), xenoestrogens (plastics, pesticides), constipation (estrogen reabsorption), obesity (aromatase in fat). Symptoms: PMS, heavy periods, breast tenderness, fibrocystic breasts, mood swings, weight gain, fibroids, endometriosis. Estrogen metabolism crucial - "good" pathway (2-hydroxyestrogen) vs "bad" pathways (4-OH, 16-OH more carcinogenic). DIM/I3C shift to 2-OH pathway. Calcium-d-glucarate prevents beta-glucuronidase (bacterial enzyme) from deconjugating estrogen in gut (estrobolome). Daily bowel movement essential. Progesterone cream effective but use bioidentical, not synthetic. John Lee pioneered natural progesterone. Topical avoids first-pass liver metabolism. Xenoestrogens add to burden - BPA, phthalates, parabens, pesticides. Filter water (atrazine is estrogenic). DUTCH test shows estrogen metabolites and metabolized estrogen:progesterone ratio.

Also Effective For

Hormone Imbalance

Key Supplements & Herbs in This Protocol

Supplements

Pregnenolone

Herbs

Milk Thistle

Silybum marianum

Critical Safety Warning

This protocol is documented for educational purposes only. The Gabriel Bullshit Score (GBS) of 80 reflects significant institutional response and controversy. Some alternative health protocols have resulted in serious harm or death.

Always consult with qualified healthcare professionals before beginning any treatment. Do not delay or forego proven medical care.

Quick Overview

Evidence LevelModerate

GBS Score80 / 100

Categorynutrition

DeveloperJohn Lee, Sara Gottfried, functional medicine

Duration3-6 months to rebalance hormones

About GBS Score

The Gabriel Bullshit Score reflects the magnitude of institutional response, controversy, and documented concerns. Higher scores indicate greater institutional pushback, not necessarily inefficacy. This is a research tool, not medical advice.