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Longevity
Therapeutic Plasma Exchange (TPE)
2-4 hours
·$5,000 - $15,000
·Non-invasive
What you'll experience
Therapeutic Plasma Exchange represents the frontier of longevity medicine—a sophisticated blood filtration procedure that selectively removes your plasma (the liquid portion of blood containing proteins, antibodies, clotting factors, and accumulated molecular debris) and replaces it with fresh albumin solution. In doing so, TPE effectively clears decades of accumulated inflammatory proteins, autoantibodies, senescent signaling factors, and other molecular "noise" that drives chronic inflammation and accelerates biological aging.
The science emerged from an unexpected place: parabiosis research. When scientists surgically joined the circulatory systems of old and young mice, the old mice experienced remarkable rejuvenation—improved cognition, muscle repair, and organ function. Further investigation revealed that it wasn't the young blood providing magical factors; rather, it was the dilution and removal of harmful old-blood factors that drove the benefits. Therapeutic Plasma Exchange achieves this same dilution effect in humans, without needing young blood at all.
TPE is already an established medical procedure used for autoimmune conditions like Guillain-Barré syndrome, myasthenia gravis, and thrombotic thrombocytopenic purpura. What's new is its application in longevity medicine, where emerging research suggests that periodic plasma exchange can reduce inflammatory burden, improve biomarkers of aging, and potentially slow or partially reverse aspects of biological aging. Leading longevity clinics now offer TPE as their most premium and scientifically compelling anti-aging intervention.
What's included
Extensive pre-procedure workup including comprehensive blood panels and medical clearance
IV placement in both arms or via a temporary central catheter for optimal flow rates
2-4 hours as your blood is drawn, separated via centrifuge, and plasma replaced with fresh albumin
Continuous monitoring of vital signs, electrolytes, and coagulation parameters by medical staff
Mild lightheadedness or tingling (from citrate anticoagulant) managed with calcium supplementation
Post-procedure observation, lab work, and detailed follow-up plan (typically 3-5 sessions per protocol)
Who this is for
Individuals committed to cutting-edge longevity interventions
Those with elevated inflammatory markers unresponsive to standard approaches
People with autoimmune conditions seeking advanced management
High-net-worth individuals investing in maximum healthspan extension
Biohackers and longevity enthusiasts pursuing the most advanced available therapies
Key benefits
Removal of accumulated inflammatory proteins and aging factors from circulation
Reduction in autoantibodies and pathological immune complexes
Potential improvement in biological age biomarkers
Decreased systemic inflammation and inflammatory signaling
Improved cognitive clarity and neurological function
Restoration of healthier plasma protein composition
Evidence & safety
Therapeutic Plasma Exchange is an established medical procedure with FDA-recognized indications for numerous autoimmune and hematological conditions. The longevity application is supported by landmark parabiosis research published in Nature, Nature Medicine, and Science, as well as a 2022 study from UC Berkeley demonstrating that plasma dilution alone (without young blood) produced rejuvenation effects in aged mice. Human clinical trials are ongoing. TPE is performed under physician supervision with continuous monitoring. Risks include transient hypotension, citrate-related hypocalcemia, allergic reaction to replacement fluids, and rare infection at catheter sites. This is a medical procedure requiring full physician oversight.
$5,000/ session
Duration2-4 hours
Usually books within 24 hours
This treatment includes:
Initial consultation
Full treatment session
Personalized recommendations
Follow-up support
Patient Reviews
4.9
(12 reviews)
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Richard T.Verified Patient
3 weeks ago
This is the most advanced therapy I've undergone in my 15 years of pursuing longevity medicine. After three TPE sessions, my inflammatory markers dropped dramatically—CRP went from 4.2 to 0.8, and my biological age score improved by nearly 4 years on the TruAge test. The procedure itself was straightforward and the medical team was exceptional.
Victoria S.Verified Patient
2 months ago
I originally explored TPE for my autoimmune condition, but the overall rejuvenation effects were what truly amazed me. Brain fog cleared, joint pain diminished, and my energy returned to levels I hadn't felt in a decade. Yes, it's expensive, but the results are commensurate with the investment.
Howard K.Verified Patient
3 months ago
As a physician myself, I was drawn to TPE by the parabiosis research. The science is compelling and the clinical execution was flawless. My bloodwork improvements were significant across multiple inflammatory and metabolic markers. This is where longevity medicine is heading.
Reviews are from verified patients. Individual results may vary.
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