Vitamin K2 (Menaquinone)

Mechanism of Action

Activates proteins (osteocalcin, MGP) that direct calcium into bones and away from arteries

Primary Applications

Osteoporosis

Arterial calcification

Cardiovascular disease

Tooth decay

Recommended Dosage

100-200mcg/day (MK-7 or MK-4)

Available Forms

MK-4 (synthetic, shorter half-life), MK-7 (natto-derived, longer half-life)

Top Brands

ThornePure EncapsulationsLife ExtensionJarrow

Synergies

Works synergistically with:

Vitamin D3 (essential pairing)

Calcium

Magnesium

Natural Food Sources

Natto; Fermented foods; Egg yolks; Grass-fed dairy; Liver

Interactions

Antagonizes warfarin; May interact with antibiotics (gut bacteria produce K2)

Contraindications

Warfarin use (without monitoring)

Clinical Notes

MK-7 preferred for longer half-life; essential partner to D3; prevents 'calcium paradox' (soft tissue calcification)

Conditions This Helps

Osteoporosis

Quick Overview

CategoryVitamins

GBS Score88/100

IDV013

Key Points

Evidence-based dosing

Mechanism documented

Interaction screening

Synergy optimization

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This information is for educational purposes. Always consult with a qualified healthcare provider before starting any new supplement protocol.

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