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Gabriel distinguishes histamine intolerance (DAO deficiency, impaired breakdown) from MCAS (mast cells excessively releasing histamine).
Gabriel distinguishes histamine intolerance (DAO deficiency, impaired breakdown) from MCAS (mast cells excessively releasing histamine). Comprehensive testing identifies: DAO enzyme level, histamine level, tryptase (MCAS), genetic variants, gut health, underlying triggers (mold, infections). Protocol: 1) Low-histamine diet (temporary—4-8 weeks), 2) Support DAO enzyme, 3) Stabilize mast cells, 4) Heal gut (root cause), 5) Address underlying triggers (infections, mold, stress), 6) Support histamine metabolism pathways. Goal: expand food tolerance, not lifelong restriction.
Standard Treatment
H1 antihistamines (Claritin, Zyrtec, Benadryl), H2 blockers (Pepcid, Zantac), Mast cell stabilizers (Cromolyn sodium/Gastrocrom for MCAS), Quercetin (sometimes recommended), Avoid histamine-rich foods (but minimal guidance), Corticosteroids for severe MCAS.
The Problem
Antihistamines block symptoms but don't address root cause (DAO deficiency, gut dysfunction, underlying infections/mold), tolerance develops, side effects (drowsiness, dry mouth), H2 blockers reduce stomach acid (worsens gut dysfunction long-term), Cromolyn expensive and requires multiple daily doses, conventional medicine doesn't test DAO enzyme or investigate gut dysfunction comprehensively, MCAS often dismissed or misdiagnosed, minimal dietary guidance, doesn't address methylation support, underlying infections, or toxin exposure.
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Whole food supplements by Standard Process
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Standard Process + Matter peptides
Strict low-histamine diet Phase 1 (4-8 weeks minimum): Avoid high-histamine foods: aged cheese, cured meats, fermented foods (sauerkraut, kimchi, yogurt, kefir, kombucha), alcohol (especially wine), vinegar, leftover/reheated foods (histamine increases with age), spinach, eggplant, tomatoes, avocado, shellfish, canned fish, dried fruits, chocolate, most nuts; Histamine-releasing foods: citrus, strawberries, bananas, pineapple, papaya, egg whites, pork, certain fish; Eat: fresh meat/poultry, fresh fish (flash frozen immediately after catch), most vegetables, rice, quinoa, coconut products, olive oil, herbs; Reintroduce systematically after symptoms improve.
Stress management paramount (stress triggers mast cell degranulation), adequate sleep, address mold exposure (major MCAS trigger), avoid extreme temperatures, avoid strong smells/fragrances (trigger mast cells), gentle exercise (intense exercise releases histamine), support gut health, methylation support, stay hydrated, avoid NSAIDs and other DAO-blocking medications, keep medications/supplements cold (some degrade and form histamine).
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Mind, Body & Spirit
True healing requires addressing all dimensions of health. These evidence-based practices complement physical treatment protocols.
Meditation and breathwork to reduce stress-triggered mast cell activation.
Cold exposure, humming, gargling to modulate immune and mast cell response.
Walking and stretching without triggering histamine release from intense exercise.
Addressing trauma and emotional stress that trigger mast cell activation.
Cultivating physical and emotional environments that feel safe and non-triggering.
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